Funke A M
Universitäts-Frauenklinik Köln.
Med Klin (Munich). 1999 Oct 15;94 Suppl 3:42-4. doi: 10.1007/BF03042190.
Studies on potential benefits of selenite in cancers of the female genital tract and breast cancer have concentrated on 2 fields: prevention on one side, complementary oncological therapy on the other side. Big studies have been realized in the past which have shown no clear effect of selenium supplementation in prevention of female cancers and breast cancer in the industrialized nations of Europe and Northern America. Few investigations exist on the therapeutic effects of selenium therapy in the clinical field of gyneco-oncology.
Many patients with malignant disease of the female breast and genital tract are strongly demanding additional therapeutical concepts in natural medicine in addition to adjuvant or palliative chemo- or hormonal therapy and supportive medication. In pilot studies with low-dose natrium selenite (up to 300 micrograms/day) they report a better quality of life. Side effects were not reported. Analysis of the immune system reveal a stimulation of B19 lymphocytes and natural killer cells.
In Germany, a country with selenium deficiency, clinical studies are now carried out on the effects of selenium as a drug to reduce side effects of chemo- and radiotherapy, enhance quality of life by reducing toxic side effects and help to restore immune function.
关于亚硒酸盐在女性生殖道癌和乳腺癌中的潜在益处的研究主要集中在两个领域：一方面是预防，另一方面是辅助肿瘤治疗。过去已经开展了大型研究，结果表明在欧洲和北美的工业化国家，补充硒对预防女性癌症和乳腺癌没有明显效果。在妇科肿瘤临床领域，关于硒疗法治疗效果的研究很少。
许多患有女性乳腺和生殖道恶性疾病的患者，除了辅助或姑息性化疗、激素治疗以及支持性药物治疗外，强烈要求采用自然医学中的其他治疗理念。在低剂量亚硒酸钠（每日高达300微克）的试点研究中，患者报告生活质量有所改善。未报告有副作用。对免疫系统的分析显示B19淋巴细胞和自然杀伤细胞受到刺激。
在德国这个缺硒国家，目前正在开展临床研究，以探讨硒作为一种药物，在减轻化疗和放疗副作用、通过减少毒性副作用提高生活质量以及帮助恢复免疫功能方面的效果。
