van Noord P A, Collette H J, Maas M J, de Waard F
Int J Epidemiol. 1987 Jun;16(2):318-22. doi: 10.1093/ije/16.2.318.
To determine the possible role of selenium in the pathogenesis of breast cancer, prediagnostic Se 77 m isotope levels in toenail clippings in premenopausal women were measured. The study was designed as a case-referent study nested in a cohort. Participants were recruited from the DOM-project breast-cancer screening cohorts. No decreased selenium levels were found up to two years prior to diagnosis, nor were Se levels different between prevalent and/or incident breast cancer cases, referents and women with benign breast disease. Se levels measured in nails could not detect women at higher risk for breast cancer. This study does not support the idea that Se supplementation could have a preventive potential for premenopausal breast cancer in women in the Netherlands.
为了确定硒在乳腺癌发病机制中的可能作用，对绝经前女性脚趾甲剪片的诊断前硒77m同位素水平进行了测量。该研究设计为嵌套在队列中的病例对照研究。参与者从DOM项目乳腺癌筛查队列中招募。在诊断前两年内未发现硒水平降低，在现患和/或新发病例、对照以及患有良性乳腺疾病的女性之间，硒水平也没有差异。指甲中测量的硒水平无法检测出乳腺癌风险较高的女性。本研究不支持补充硒对荷兰女性绝经前乳腺癌具有预防潜力这一观点。
