钌催化末端炔烃与苯胺的分子间氢胺化反应：芳香酮亚胺的实用合成方法
Ruthenium-Catalyzed Intermolecular Hydroamination of Terminal Alkynes with Anilines: A Practical Synthesis of Aromatic Ketimines.
作者信息
Tokunaga M, Eckert M, Wakatsuki Y
机构信息
The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama, 351-0198 (Japan).
出版信息
Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3222-3225. doi: 10.1002/(sici)1521-3773(19991102)38:21<3222::aid-anie3222>3.0.co;2-7.
Without solvent and in the open air, the hydroamination of phenylacetylene with aniline in the presence of [Ru(3)(CO)(12)]/NH(4)PF(6) proceeds with high regioselectivity [Eq. (1)]. Simple distillation gives a product with greater than 99 % purity in an excellent yield. The application of this method to a new two-component reaction gives the important class of substances: the quinolines.
在无溶剂且露天的条件下，苯乙炔与苯胺在[Ru₃(CO)₁₂]/NH₄PF₆存在下进行氢胺化反应时具有较高的区域选择性[式(1)]。简单蒸馏即可得到纯度大于99%且产率优异的产物。将该方法应用于一种新型的两组分反应可得到一类重要的物质：喹啉。
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