Prescrire Int. 1999 Feb;8(39):24-8.
(1) Treatment with zidovudine has led to a fall in the mother-to-child HIV transmission during pregnancy and the first few weeks of neonatal life. (2) Ongoing trials are assessing the preventive efficacy of two-drug and three-drug antiretroviral regimens in this setting. (3) Pending the results of these studies, treatment with zidovudine is recommended for all HIV-infected pregnant women. (4) Current therapeutic strategies may lead to the prescription or continuation of multidrug antiretroviral regimens for seropositive pregnant women. (5) Available information on the possible adverse effects of antiretroviral drugs on the pregnant woman, fetus and child are limited. (6) Two reports propose similar guidelines for the management of seropositive pregnant women and their children during the first weeks of life.
(1) 使用齐多夫定进行治疗已使孕期及新生儿生命最初几周的母婴艾滋病毒传播率有所下降。(2) 正在进行的试验正在评估在此情况下两药和三药抗逆转录病毒方案的预防效果。(3) 在这些研究结果出来之前，建议对所有感染艾滋病毒的孕妇使用齐多夫定进行治疗。(4) 当前的治疗策略可能导致为血清反应阳性的孕妇开具或继续使用多药抗逆转录病毒方案。(5) 关于抗逆转录病毒药物对孕妇、胎儿和儿童可能产生的不良反应的现有信息有限。(6) 两份报告针对血清反应阳性的孕妇及其子女在生命最初几周的管理提出了类似的指导方针。
Zotero 插件