效应细胞非依赖II类分子产生CD4记忆性T细胞。

Class II-independent generation of CD4 memory T cells from effectors.

作者信息

Swain S L, Hu H, Huston G

机构信息

Biomedical Research Laboratories, Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA.

出版信息

Science. 1999 Nov 12;286(5443):1381-3. doi: 10.1126/science.286.5443.1381.

DOI:10.1126/science.286.5443.1381

PMID:10558997

Abstract

The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naïve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition.

摘要

记忆性CD4 T细胞产生所需的因素仍不清楚，而抗原刺激是否持续存在对于疫苗策略的设计至关重要。从小鼠初始CD4 T细胞体外产生的CD4效应细胞转移至II类缺陷宿主后，可有效地产生少量静息性记忆细胞，这表明不需要进一步的抗原或II类识别。