IgG针对单核细胞受体的效应位点定位
Localization of the IgG effector site for monocyte receptors.
作者信息
Ciccimarra F, Rosen F S, Merler E
出版信息
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2081-3. doi: 10.1073/pnas.72.6.2081.
Abstract
A peptide consisting of 10 amino acids derived from the CH3 region of human IgG was shown to bind to monocytes and to inhibit rosette formation of antibody-coated erythrocytes with human monocytes. Two myeloma proteins of the IgG1 and IgG3 subclass, both with known deletions in the CH2 region of the gamma chain, showed unimpaired ability to bind to monocytes. These experiments suggest that the isolated peptide represents the primary site of attachment of IgG to monocytes.
摘要
一种由源自人IgG CH3区域的10个氨基酸组成的肽，被证明能与单核细胞结合，并抑制抗体包被的红细胞与人单核细胞的玫瑰花结形成。两种IgG1和IgG3亚类的骨髓瘤蛋白，其γ链的CH2区域均有已知缺失，它们与单核细胞结合的能力未受损害。这些实验表明，分离出的肽代表了IgG与单核细胞结合的主要位点。
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