Harvei S
Institutt for epidemiologisk kreftforskning Montebello, Oslo.
Tidsskr Nor Laegeforen. 1999 Oct 10;119(24):3589-94.
Prostate cancer is the most common type of cancer in Norway, with more than 2,400 new cases each year. Hormones, diet, and chemical and genetic factors are implicated in the aetiology. It is not clear whether alcohol and tobacco increase the risk of prostate cancer. Median age at diagnosis is 74-75 years. The incidence has increased steadily with a doubling of the number of cases over 20-25 year periods. Prostate cancer mortality in Norway is the highest among the Nordic countries and among the highest in the world. Five-year relative survival for all cases combined is 60%. Approximately 55-60% of the patients dies from the disease. The incidence is lower in the three northernmost counties. Elsewhere in the country the incidence varies between counties according to variations in diagnostic practice. Serological analysis of Prostate Specific Antigen after 1990 has lead to an increase in the number of new cases, mainly because of earlier diagnosis. Prostate cancer is often a slowly growing tumour which is clinically asymptomatic for many years. Latent carcinoma is found at autopsy in 30-35% of men above 50 years of age. Today, prevention of prostate cancer is not feasible, though specific advice about life style and diet might decrease the risk.
前列腺癌是挪威最常见的癌症类型,每年新增病例超过2400例。病因涉及激素、饮食以及化学和遗传因素。尚不清楚酒精和烟草是否会增加患前列腺癌的风险。诊断时的中位年龄为74 - 75岁。发病率稳步上升,在20 - 25年期间病例数翻了一番。挪威的前列腺癌死亡率在北欧国家中最高,在世界上也位居前列。所有病例综合的五年相对生存率为60%。约55 - 60%的患者死于该疾病。最北部的三个县发病率较低。在该国其他地区,发病率因各县诊断实践的差异而有所不同。1990年后对前列腺特异性抗原的血清学分析导致新病例数增加,主要是因为诊断提前。前列腺癌通常是一种生长缓慢的肿瘤,多年来临床上无症状。在50岁以上男性的尸检中,30 - 35%发现有潜伏癌。如今,前列腺癌的预防尚不可行,不过关于生活方式和饮食的具体建议可能会降低风险。