Engeland A, Tretli S, Bjørge T
Division of Epidemiology, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N-0403 Oslo, Norway.
Br J Cancer. 2003 Oct 6;89(7):1237-42. doi: 10.1038/sj.bjc.6601206.
The present study explored body mass index (BMI), height, and risk of prostate cancer in a large Norwegian cohort of 950000 men aged 20-74 years, whose height and weight were measured in a standardised way in the period 1963-1999. These were followed for an average of 21 years. The Cox proportional hazard models were used in the analyses. During follow-up, 33 300 histologically verified cases of prostate cancer were registered. The risk of prostate cancer increased by both BMI and height. The magnitude of the increase by BMI was modest, the relative risk (RR) of obese men (BMI>or=30) compared with normal weighted was 1.09 (95% CI: 1.04-1.15). However, the RR at age 50-59 years was 1.58 (95% CI: 1.29-1.94) in men being obese at about age 45 years compared with normal weighted men. The tallest men had an RR of 1.72 (95% CI: 1.46-2.04) compared with the shortest men. The overall effect of BMI on the incidence of prostate cancer was modest. The larger effect found in men aged 50-59 years might partly explain the previous inconsistent findings.
本研究在挪威一个由950000名年龄在20 - 74岁男性组成的大型队列中，探讨了体重指数（BMI）、身高与前列腺癌风险之间的关系。这些男性的身高和体重在1963年至1999年期间以标准化方式进行了测量。随后对他们进行了平均21年的随访。分析中使用了Cox比例风险模型。在随访期间，共登记了33300例经组织学证实的前列腺癌病例。前列腺癌风险随BMI和身高的增加而升高。BMI增加的幅度较小，肥胖男性（BMI≥30）与正常体重男性相比，相对风险（RR）为1.09（95%可信区间：1.04 - 1.1）。然而，在大约45岁时肥胖的男性，50 - 59岁时的RR为1.58（95%可信区间：1.29 - 1.94），而与正常体重男性相比。最高的男性与最矮的男性相比，RR为1.72（95%可信区间：1.46 - 2.04）。BMI对前列腺癌发病率的总体影响较小。在50 -所发现的较大影响可能部分解释了先前不一致的研究结果。
（注：原文中“95% CI: 1.04 - 1.1”括号内的数字有误，翻译时保留了原文错误，正确应为“95% CI: 1.04 - 1.15”）
