Kim Y W, Park Y K, Park J H, Lee J, Lee S M, Hong S W, Yang M H
Department of Pathology, College of Medicine, Kyung Hee University, Seoul, Korea.
Yonsei Med J. 1999 Oct;40(5):506-9. doi: 10.3349/ymj.1999.40.5.506.
Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) is sometimes found in resected livers, however, cases with double cancer of HCC and CC are very rare. As well, the rarity of CC arising in von Meyenburg complexes (VMCs) is appreciated. We report the case of a 74-year-old man found to have intrahepatic double cancer composed of well-differentiated HCC and CC which exhibited a histologic progression from VMCs to adenomatous lesions and CC. To our knowledge, this is the first case report published in the literature of a double HCC and CC associated with multiple VMCs. The pathogenesis and previous associated reports of these lesions are discussed.
在切除的肝脏中有时会发现合并肝细胞癌（HCC）和胆管癌（CC）的情况，然而，HCC和CC双癌病例非常罕见。同样，在肝内胆管错构瘤（VMCs）中发生CC的情况也很罕见。我们报告了一例74岁男性病例，该患者被发现患有由高分化HCC和CC组成的肝内双癌，其组织学表现为从VMCs进展为腺瘤样病变再到CC。据我们所知，这是文献中发表的首例与多个VMCs相关的HCC和CC双癌病例报告。本文讨论了这些病变的发病机制及既往相关报道。
