Vanzetta I, Grinvald A
Department of Neurobiology, Center for Research of Higher Brain Functions, Weizmann Institute of Science, Rehovot 76100, Israel.
Science. 1999 Nov 19;286(5444):1555-8. doi: 10.1126/science.286.5444.1555.
Modern functional brain mapping relies on interactions of neuronal electrical activity with the cortical microcirculation. The existence of a highly localized, stimulus-evoked initial deoxygenation has remained a controversy. Here, the activity-dependent oxygen tension changes in the microcirculation were measured directly, using oxygen-dependent phosphorescence quenching of an exogenous indicator. The first event after sensory stimulation was an increase in oxygen consumption, followed by an increase in blood flow. Because oxygen consumption and neuronal activity are colocalized but the delayed blood flow is not, functional magnetic resonance imaging focused on this initial phase will yield much higher spatial resolution, ultimately enabling the noninvasive visualization of fundamental processing modules in the human brain.
现代功能性脑图谱依赖于神经元电活动与皮质微循环的相互作用。高度局部化的、刺激诱发的初始脱氧现象的存在一直存在争议。在此，我们使用外源性指示剂的氧依赖性磷光猝灭直接测量了微循环中与活动相关的氧张力变化。感觉刺激后的第一个事件是氧消耗增加，随后是血流增加。由于氧消耗与神经元活动共定位，但延迟的血流并非如此，专注于这一初始阶段的功能磁共振成像将产生更高的空间分辨率，最终能够无创地可视化人类大脑中的基本处理模块。
