Fink-Gremmels J
Division of Veterinary Pharmacy, Pharmacology and Toxicology, Utrecht University, The Netherlands.
Vet Q. 1999 Oct;21(4):115-20. doi: 10.1080/01652176.1999.9695005.
Mycotoxins contaminate various feed and food commodities, due to the global occurrence of toxinogenic molds. They exert adverse health effects in human and animals. The nature of these toxic effects varies depending on the chemical structure of the toxin. The degree of these adverse effects is not only determined by the toxin concentration present in foods and feeds, but also by the time of exposure. Whilst in animals, next to acute intoxication, losses in productivity, reduced weight gain and immunosuppression are considered as most important feature of mycotoxicoses, genotoxic effects and the involvement of certain mycotoxins such as aflatoxin, ochratoxins and fumonisins in the etiology of human cancers have obtained particular attention. This implies that recent research activities concentrate on mechanistic aspects of mycotoxin-induced pathologies, rather than compiling analytical measures of mycotoxin concentrations in food and feeds.
由于产毒霉菌在全球范围内存在，霉菌毒素会污染各种饲料和食品。它们会对人类和动物产生不良健康影响。这些毒性作用的性质因毒素的化学结构而异。这些不良影响的程度不仅取决于食品和饲料中存在的毒素浓度，还取决于接触时间。在动物中，除了急性中毒外，生产力下降、体重增加减少和免疫抑制被认为是霉菌毒素中毒最重要的特征，而某些霉菌毒素如黄曲霉毒素、赭曲霉毒素和伏马菌素在人类癌症病因中的遗传毒性作用和参与情况受到了特别关注。这意味着最近的研究活动集中在霉菌毒素诱导的病理机制方面，而不是汇编食品和饲料中霉菌毒素浓度的分析方法。
