Effects in food-producing animals.

Unexplained disease outbreaks in farm and domestic animals have suggested the likely presence of mycotoxins in feeds for many years. The manifestations of mycotoxicoses in the field are frequently nondescript and potentially have many contributing factors, which are often difficult to define. Nevertheless, toxigenic moulds were implicated in, and sometimes proven to be the cause of, animal disease in field outbreaks long before the toxins were discovered. The development of methods for the chemical analysis of mycotoxins in feeds and animal tissues has contributed to an improved understanding of the dose-response relationships of farm animal diseases associated with exposure to aflatoxins, fumonisins, ochratoxin A, deoxynivalenol, zearalenone, and ergot alkaloids. In all cases the effect of mycotoxins on animal performance is potentially a major problem for farmers regardless of their scale of operation. Reduced growth, decreased egg and milk production, lower reproductive efficiency, and increased susceptibility to stress are all potentially devastating consequences of mycotoxin exposure. Thus, being aware of the outward signs that might signal the involvement of a mycotoxin in an animal performance problem is the first step to minimizing potential adverse impacts. The target organ affected can provide important clues to involvement of a specific mycotoxin, in which case understanding the toxicokinetics and toxicology will assist in minimizing the cost and maximizing the effectiveness of interventions. The primary objective of this chapter is to provide information that will aid in the field identification of the possible involvement of a mycotoxin in an animal production problem. In conjunction with the information provided in the other chapters, this information will assist farmers in making decisions that will minimize losses due to diseases induced by mycotoxins.