Calabrese V, Randazzo S D, Catalano C, Rizza V
Faculty of Medicine, Dept. of Chemistry, University of Catania, Italy.
Drugs Exp Clin Res. 1999;25(5):219-25.
It is generally accepted that lipid peroxides play an important role in the pathogenesis of free radical-induced cellular injury and that antioxidants such as glutathione, ascorbic acid and alpha-tocopherol are vital in cellular defense against endogenous and exogenous oxidants. The purpose of this study was to investigate the effectiveness of a natural compound, derived from lemon oil extract, in controlling free radical-induced lipid peroxidation and tissue damage in the skin. We provide evidence that a compound isolated from lemon oil, which we have called Lem1, is endowed with a strong antioxidant activity and that it is capable of inhibiting free radical-mediated reactions, evaluated by both in vitro and in vivo biochemical systems. The present study aims to give a preclinical perspective on the biochemical properties of Lem1, a natural compound, as well as to provide a better understanding of the endogenous antioxidant potential of skin and the real validity of a natural antioxidant biotechnology in the antiaging management of the skin.
一般认为，脂质过氧化物在自由基诱导的细胞损伤发病机制中起重要作用，而谷胱甘肽、抗坏血酸和α-生育酚等抗氧化剂在细胞抵御内源性和外源性氧化剂方面至关重要。本研究的目的是调查一种源自柠檬油提取物的天然化合物在控制自由基诱导的皮肤脂质过氧化和组织损伤方面的有效性。我们提供的证据表明，从柠檬油中分离出的一种化合物（我们称之为Lem1）具有很强的抗氧化活性，并且能够抑制自由基介导的反应，这是通过体外和体内生化系统评估得出的。本研究旨在从临床前角度阐述天然化合物Lem1的生化特性，以及更好地理解皮肤的内源性抗氧化潜力和天然抗氧化生物技术在皮肤抗老化管理中的实际有效性。
