Rovenský J, Lackovic V, Veselková Z, Horváthová M, Koska J, Blazícková S, Vigas M
Research Institute of Rheumatic Diseases, Piest'any, Slovakia.
Int J Tissue React. 1999;21(2):43-9.
We investigated the in vitro effect of domperidone-induced hyperprolactinemia on plasma cytokine concentration and blood leukocyte cytokine production in healthy female volunteers. No changes were found in the plasma concentration of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-4, IL-10, IL-6 and IL-13 during hyperprolactinemia when compared with control values. Using unseparated blood leukocytes, we found that the spontaneous production of IL-6 (4-8 h) and transforming growth factor (TGF)-beta 1 (2-4 h) was significantly decreased and that the in vitro stimulated production of IFN-gamma (2-8 h) and TNF (4 h) was significantly increased compared with control. Our data concerning the increased IFN-gamma and TNF producing capacity of unseparated leukocytes during pharmacologically induced hyperprolactinemia strongly support the possibility that the lymphocyte production of these cytokines can be rapidly amplified by prolactin via a priming mechanism.
我们在健康女性志愿者中研究了多潘立酮诱导的高催乳素血症对血浆细胞因子浓度及血液白细胞细胞因子产生的体外影响。与对照值相比，高催乳素血症期间干扰素（IFN）-γ、肿瘤坏死因子（TNF）-α、白细胞介素（IL）-4、IL-10、IL-6和IL-13的血浆浓度未发现变化。使用未分离的血液白细胞，我们发现与对照相比，IL-6（4 - 8小时）和转化生长因子（TGF）-β1（2 - 4小时）的自发产生显著降低，而IFN-γ（2 - 8小时）和TNF（4小时）的体外刺激产生显著增加。我们关于药理学诱导的高催乳素血症期间未分离白细胞产生IFN-γ和TNF能力增加的数据有力地支持了催乳素可能通过启动机制快速放大这些细胞因子淋巴细胞产生的可能性。
