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[Dopamine antibodies: effect on the "open field" behavior, pain sensitivity, monoamine levels in the central nervous system, and functional activity of immunocytes in C57Bl/6 mice].

作者信息

Trekova N A, Vetrilé L A, Basharova L A, Mikovskaia O I, Khlopushina T G

机构信息

Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 Sep-Oct;49(5):799-807.

PMID:10570535
Abstract

Dopamine antibodies (AB) were singularly injected to C57B1/6 mice intraperitoneally. The locomotor activity in the open field was suppressed for 5 days in the majority of the animals. Hyperalgesia revealed 1.5 h and 1 day after the AB injection changed for analgesia on the 5th day. A sharp reduction of the brain level of dopamine and its metabolite was revealed 1 and 5 days after the AB injection, the serotonin content was increased within 1 day and decreased within 5 days after the injection. No action of the AB on cells of the immune system was observed. The possible mechanisms of the AB neurotropic action are discussed.

摘要

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