Trekova N A, Vetrilé L A, Basharova L A, Mikovskaya O I, Khlopushina T G
Science Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Neurosci Behav Physiol. 2001 Jan-Feb;31(1):7-13. doi: 10.1023/a:1026661811317.
Single i.p. doses of anti-dopamine antibodies were given to C57Bl/6 mice. This resulted in inhibition of motor activity in a large proportion of the animals in the "open field" test, which lasted five days. Hyperalgesia, detected 1.5 h and 1 day after doses of antibody, was replaced by analgesia on day 5. There was a sharp reduction in the levels of dopamine and its metabolites in the cerebral cortex at 1 and 5 days; the serotonin level was increased 1 day after doses of antibody, and was significantly decreased at 5 days. There was no effect on cells of the immune system. The possible mechanisms of the neurotropic action of these antibodies are discussed.
