共轭亚油酸异构体对体外肝微粒体去饱和活性的影响。
Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro.
作者信息
Bretillon L, Chardigny J M, Grégoire S, Berdeaux O, Sébédio J L
机构信息
INRA, Unité de Nutrition Lipidique, Dijon, France.
出版信息
Lipids. 1999 Sep;34(9):965-9. doi: 10.1007/s11745-999-0446-9.
The influence of individual conjugated linoleic acid (CLA) isomers on the delta6 desaturation of linoleic and alpha-linolenic acids and on the delta9 desaturation of stearic acid was investigated in vitro, using rat liver microsomes. The delta6 desaturation of 18:2n-6 was decreased from 23 to 38% when the ratio of 9cis,11trans-18:2 to 18:2n-6 increased from 0.5 to 2. The compound 10trans,12cis-18:2 exhibited a similar effect only at the highest concentration. The delta6 desaturation of alpha-linolenic acid was slightly affected by the presence of CLA isomers. The sole isomer to induce an inhibitory effect on the delta9 desaturation of stearic acid was 10trans,12cis-18:2.
利用大鼠肝脏微粒体在体外研究了单个共轭亚油酸（CLA）异构体对亚油酸和α-亚麻酸的Δ6去饱和作用以及对硬脂酸的Δ9去饱和作用的影响。当9顺式，11反式-18:2与18:2n-6的比例从0.5增加到2时，18:2n-6的Δ6去饱和作用从23%降至38%。化合物10反式，12顺式-18:2仅在最高浓度时表现出类似作用。CLA异构体的存在对α-亚麻酸的Δ6去饱和作用影响轻微。对硬脂酸的Δ9去饱和作用产生抑制作用的唯一异构体是10反式，12顺式-18:2。
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