Suppr超能文献

[老年急性胆源性胰腺炎在内镜腹腔镜时代的治疗]

[Treatment of acute biliary pancreatitis in the aged in the endolaparoscopic era].

作者信息

Schietroma M, Lattanzio R, Risetti A, Di Placido R, Carlei F, Leardi S, Mattucci S, Bellucci N, Pistoia M A, Simi M

机构信息

Dipartimento di Discipline Chirurgiche, Università degli Studi, L'Aquila.

出版信息

Minerva Chir. 1999 Oct;54(10):677-84.

Abstract

BACKGROUND

Acute biliary pancreatitis (ABP) still retains high morbidity (15-50%) and mortality (20-35%). Therefore it appears to be crucial to clearly assess the aetiological factors (50% of idiopathic are in fact biliary pancreatitis) and to establish the severity in order to plan the appropriate treatment.

METHODS

In this study we have considered 61 patients divided into 2 groups. Group 1 had 29 ABP patients aging less than 65 years, group 232 patients aging more than 65 years; the diagnosis was made by ultrasound and serological values in 78.5% of cases, while in the remaining 21.5% was only serological. Following Ranson and APACHE II scoring 18 cases (29.5%) were classified as severe [6 (20.6%) in group 1; 12 (37.5%) in group 2: p < 0.01], 43 (70.4%) as mild. All patients with severe ABP had emergency ERCP + ES (within 24-48 hrs) followed by LC (< or = 10 days). Patients with mild ABP had LC within 10 days; in these cases IOC was always done.

RESULTS

In severe cases operative endoscopy cured pancreatic inflammation in 13 cases. Subsequent LC never showed serious morbidity, apart subcutaneous emphysema in one case. In 5 cases laparotomy was required since pancreatic necrosis was present, with 60% mortality. In patients with mild pancreatitis LC was successfully performed in all cases, with 6.9% morbidity. IOC showed choledochal stones in 32.5% of cases, while in severe cases stones in the biliary tree were showed in 88.8% of cases. No significant differences were detected between group 1 and 2.

CONCLUSIONS

In conclusion ABP treatment is always surgical, and almost always with minimally-invasive procedures in severe cases (ERCP + ES with LC < or = 10 days) if surgery is performed within 24-48 hrs as well as in mild cases (LC + IOC) when surgery is done within 10 days, independently from the age of the patients.

摘要

背景

急性胆源性胰腺炎(ABP)的发病率(15 - 50%)和死亡率(20 - 35%)仍然居高不下。因此,明确评估病因(50%的特发性胰腺炎实际上是胆源性胰腺炎)并确定严重程度以规划适当的治疗方案显得至关重要。

方法

本研究纳入61例患者,分为两组。第1组有29例年龄小于65岁的ABP患者,第2组有32例年龄大于65岁的患者;78.5%的病例通过超声和血清学检查确诊,其余21.5%仅通过血清学检查确诊。根据兰森和急性生理与慢性健康状况评分系统(APACHE II)评分,18例(29.5%)被归类为重症[第1组6例(20.6%);第2组12例(37.5%):p < 0.01],43例(70.4%)为轻症。所有重症ABP患者在24 - 48小时内进行急诊内镜逆行胰胆管造影术(ERCP)+内镜括约肌切开术(ES),随后在10天内进行腹腔镜胆囊切除术(LC)。轻症ABP患者在10天内进行LC;在这些病例中均进行了术中胆管造影(IOC)。

结果

在重症病例中,手术内镜治疗使13例患者的胰腺炎症得到治愈。随后的LC除1例出现皮下气肿外,均未出现严重并发症。5例因存在胰腺坏死而需要开腹手术,死亡率为60%。在轻症胰腺炎患者中,所有病例的LC均成功完成,并发症发生率为6.9%。IOC显示32.5%的病例存在胆总管结石,而在重症病例中,88.8%的病例显示胆管树中有结石。第1组和第2组之间未检测到显著差异。

结论

总之,ABP的治疗始终是手术治疗,对于重症病例(在24 - 48小时内进行手术时采用ERCP + ES并在10天内进行LC)以及轻症病例(在10天内进行手术时采用LC + IOC),几乎总是采用微创手术,与患者年龄无关。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验