Schietroma M, Lattanzio R, Risetti A, Di Placido R, Carlei F, Leardi S, Mattucci S, Bellucci N, Pistoia M A, Simi M
Dipartimento di Discipline Chirurgiche, Università degli Studi, L'Aquila.
Minerva Chir. 1999 Oct;54(10):677-84.
Acute biliary pancreatitis (ABP) still retains high morbidity (15-50%) and mortality (20-35%). Therefore it appears to be crucial to clearly assess the aetiological factors (50% of idiopathic are in fact biliary pancreatitis) and to establish the severity in order to plan the appropriate treatment.
In this study we have considered 61 patients divided into 2 groups. Group 1 had 29 ABP patients aging less than 65 years, group 232 patients aging more than 65 years; the diagnosis was made by ultrasound and serological values in 78.5% of cases, while in the remaining 21.5% was only serological. Following Ranson and APACHE II scoring 18 cases (29.5%) were classified as severe [6 (20.6%) in group 1; 12 (37.5%) in group 2: p < 0.01], 43 (70.4%) as mild. All patients with severe ABP had emergency ERCP + ES (within 24-48 hrs) followed by LC (< or = 10 days). Patients with mild ABP had LC within 10 days; in these cases IOC was always done.
In severe cases operative endoscopy cured pancreatic inflammation in 13 cases. Subsequent LC never showed serious morbidity, apart subcutaneous emphysema in one case. In 5 cases laparotomy was required since pancreatic necrosis was present, with 60% mortality. In patients with mild pancreatitis LC was successfully performed in all cases, with 6.9% morbidity. IOC showed choledochal stones in 32.5% of cases, while in severe cases stones in the biliary tree were showed in 88.8% of cases. No significant differences were detected between group 1 and 2.
In conclusion ABP treatment is always surgical, and almost always with minimally-invasive procedures in severe cases (ERCP + ES with LC < or = 10 days) if surgery is performed within 24-48 hrs as well as in mild cases (LC + IOC) when surgery is done within 10 days, independently from the age of the patients.
急性胆源性胰腺炎(ABP)的发病率(15 - 50%)和死亡率(20 - 35%)仍然居高不下。因此,明确评估病因(50%的特发性胰腺炎实际上是胆源性胰腺炎)并确定严重程度以规划适当的治疗方案显得至关重要。
本研究纳入61例患者,分为两组。第1组有29例年龄小于65岁的ABP患者,第2组有32例年龄大于65岁的患者;78.5%的病例通过超声和血清学检查确诊,其余21.5%仅通过血清学检查确诊。根据兰森和急性生理与慢性健康状况评分系统(APACHE II)评分,18例(29.5%)被归类为重症[第1组6例(20.6%);第2组12例(37.5%):p < 0.01],43例(70.4%)为轻症。所有重症ABP患者在24 - 48小时内进行急诊内镜逆行胰胆管造影术(ERCP)+内镜括约肌切开术(ES),随后在10天内进行腹腔镜胆囊切除术(LC)。轻症ABP患者在10天内进行LC;在这些病例中均进行了术中胆管造影(IOC)。
在重症病例中,手术内镜治疗使13例患者的胰腺炎症得到治愈。随后的LC除1例出现皮下气肿外,均未出现严重并发症。5例因存在胰腺坏死而需要开腹手术,死亡率为60%。在轻症胰腺炎患者中,所有病例的LC均成功完成,并发症发生率为6.9%。IOC显示32.5%的病例存在胆总管结石,而在重症病例中,88.8%的病例显示胆管树中有结石。第1组和第2组之间未检测到显著差异。
总之,ABP的治疗始终是手术治疗,对于重症病例(在24 - 48小时内进行手术时采用ERCP + ES并在10天内进行LC)以及轻症病例(在10天内进行手术时采用LC + IOC),几乎总是采用微创手术,与患者年龄无关。