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[急性胆源性胰腺炎治疗中严重程度的诊断作为基本参数]

[Diagnosis of severity as a basic parameter in the treatment of acute biliary pancreatitis].

作者信息

Schietroma M, Lattanzio R, Risetti A, Rossi M, Carlei F, Cerimele M, Bellucci N, Pistoia M A, Simi M

机构信息

Cattedra di Chirurgia Generale II, Università degli Studi, L'Aquila.

出版信息

Minerva Chir. 2000 Jun;55(6):421-9.

Abstract

BACKGROUND

Acute biliary pancreatitis (ABP) still retains high morbidity (15-50%) and mortality (20-35%). Therefore it appears to be crucial to clearly assess the aetiological factors (50% of idiopathic are in fact biliary pancreatitis) and to establish their severity in order to plan the appropriate treatment.

METHODS

58 ABP patients were diagnosed by ultrasound (77.5%) or by laboratory findings (22.4%). Following Ranson and APACHE II scoring 17 cases (29.3%) were classified as severe, 41 (70.6%) as mild. All patients with severe ABP, had emergency ERCP + ES (within 24-48 hrs) followed by LC (< or = 10 days). Patients with mild ABP had LC within 10 days; in these cases IOC was always done.

RESULTS

In severe cases operative endoscopy cured pancreatic inflammation in 12 cases. Subsequent LC never showed serious morbidity, apart from subcutaneous emphysema in one case. In 5 cases laparotomy was required since pancreatic necrosis was present, with 60% mortality. In patients with mild pancreatitis LC was successfully performed in all cases, with 7.3% morbidity. IOC showed choledochal stones in 31.7% of cases, while in severe cases stones in the biliary tree were shown in 88.2% of cases.

CONCLUSIONS

In conclusion ABP treatment is always surgical, and almost always with minimally-invasive procedures in severe cases (ERCP + ES with LC < or = 10 days) if surgery is performed within 24-48 hrs as well as in mild cases (LC + IOC) when surgery is done within 10 days.

摘要

背景

急性胆源性胰腺炎(ABP)的发病率(15 - 50%)和死亡率(20 - 35%)仍然居高不下。因此,明确评估病因(50%的特发性胰腺炎实际上是胆源性胰腺炎)并确定其严重程度对于制定恰当的治疗方案似乎至关重要。

方法

58例ABP患者通过超声检查(77.5%)或实验室检查结果(22.4%)得以确诊。根据兰森和急性生理与慢性健康状况评分系统II评分,17例(29.3%)被归类为重症,41例(70.6%)为轻症。所有重症ABP患者均在24 - 48小时内接受急诊内镜逆行胰胆管造影术(ERCP)+内镜括约肌切开术(ES),随后在10天内或10天内接受腹腔镜胆囊切除术(LC)。轻症ABP患者在10天内接受LC;在这些病例中均进行了术中胆管造影(IOC)。

结果

在重症病例中,手术内镜检查使12例患者的胰腺炎症得到治愈。除1例出现皮下气肿外,后续的LC从未显示出严重的并发症。5例因存在胰腺坏死而需要开腹手术,死亡率为60%。在轻症胰腺炎患者中,所有病例均成功进行了LC,并发症发生率为7.3%。IOC显示31.7%的病例存在胆总管结石,而在重症病例中,88.2%的病例显示胆管树存在结石。

结论

总之,ABP的治疗始终是手术治疗,对于重症病例(如果在24 - 48小时内进行手术,则采用ERCP + ES并在10天内或10天内进行LC)以及轻症病例(LC + IOC,在10天内进行手术),几乎总是采用微创手术。

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