Metcalf D, Moore M A
Bibl Haematol. 1975(40):235-41. doi: 10.1159/000397538.
Cells from patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) can be grown and their properties analyzed in agar gel cultures. Levels of the glycoprotein regulator colony stimulating factor (CSF) were found to be elevated in 19-66% of plasmas tested from patients with various types of granulocytic leukemia, and the growth of AML and CML cells in vitro was observed to be dependent on, and responsive to, stimulation by CSF-containing material. In both diseases, the leukemic cells appear to be in a responsive state with respect to normal growth regulators, and potentially alterations in regulator levels may therefore be able to achieve sustained arrest of the growth of leukemic populations.
急性髓系白血病（AML）和慢性髓系白血病（CML）患者的细胞可以在琼脂凝胶培养物中生长并分析其特性。在各类粒细胞白血病患者检测的血浆中，发现19%-66%的血浆中糖蛋白调节因子集落刺激因子（CSF）水平升高，并且观察到AML和CML细胞在体外的生长依赖于含CSF物质的刺激并对其有反应。在这两种疾病中，白血病细胞似乎对正常生长调节因子处于反应状态，因此调节因子水平的潜在改变可能能够实现白血病细胞群体生长的持续停滞。
