Nieto F J, Iribarren C, Gross M D, Comstock G W, Cutler R G
Department of Epidemiology, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, room W6009, Baltimore, MD 21205, USA.
Atherosclerosis. 2000 Jan;148(1):131-9. doi: 10.1016/s0021-9150(99)00214-2.
the evidence of a potential beneficial role of antioxidants in preventing atherosclerotic disease is not entirely consistent.
to assess the longitudinal association of serum total antioxidant capacity and serum antioxidants with the presence of subclinical carotid atherosclerosis.
Prospective case-control study nested within an historical cohort. Cases were 150 individuals with elevated carotid intimal-medial thickness measured by B-mode ultrasound at the first two examinations of the Atherosclerosis Risk in Communities Study (1987-92). Controls were 150 age-gender-matched individuals with low carotid intimal-medial thickness. Serum antioxidant vitamins, uric acid, and serum total antioxidant capacity were measured in frozen serum samples collected from the same individuals in 1974 (13-15 years prior to the determination of case-control status).
Compared to controls, atherosclerosis cases had significantly higher levels of serum total antioxidant capacity in 1974 than controls. This difference was almost entirely explained by increased serum concentration of uric acid in cases. In contrast with cross-sectional results, uric acid serum concentration in 1974, was significantly higher in cases than in controls, even after adjusting for the main cardiovascular risk factors. Cases had significantly lower levels of alpha-carotene in the 1974 sera than controls, but no other differences in serum antioxidant vitamin concentrations were observed.
The higher serum uric acid concentration seemed associated with elevated total serum antioxidant capacity among individuals with atherosclerosis. This finding is consistent with experimental evidence suggesting that hyperuricemia may be a compensatory mechanism to counteract oxidative damage related to atherosclerosis and aging in humans.
抗氧化剂在预防动脉粥样硬化疾病中潜在有益作用的证据并不完全一致。
评估血清总抗氧化能力和血清抗氧化剂与亚临床颈动脉粥样硬化存在情况的纵向关联。
在一个历史队列中进行前瞻性病例对照研究。病例为150名在社区动脉粥样硬化风险研究（1987 - 92年）的前两次检查中通过B型超声测量颈动脉内膜中层厚度升高的个体。对照为150名年龄和性别匹配、颈动脉内膜中层厚度低的个体。在1974年（确定病例对照状态前13 - 15年）从相同个体采集的冷冻血清样本中测量血清抗氧化维生素、尿酸和血清总抗氧化能力。
与对照组相比，动脉粥样硬化病例在1974年的血清总抗氧化能力水平显著高于对照组。这种差异几乎完全由病例组血清尿酸浓度升高所解释。与横断面结果相反，即使在调整主要心血管危险因素后，1974年病例组的血清尿酸浓度仍显著高于对照组。病例组1974年血清中的α - 胡萝卜素水平显著低于对照组，但未观察到血清抗氧化维生素浓度的其他差异。
在动脉粥样硬化个体中，较高的血清尿酸浓度似乎与血清总抗氧化能力升高有关。这一发现与实验证据一致，表明高尿酸血症可能是一种补偿机制，以抵消与人类动脉粥样硬化和衰老相关的氧化损伤。
