Ivanoff B, Tayot J L, Creach O, Fontanges R
Bull Soc Pathol Exot Filiales. 1978 May-Jun;71(3):240-8.
The immune response to Vibrio cholerae was studied in baboons, rhesus monkeys and marmosets inoculated by the oral, intraintestinal or intravenous route with various strains of V. cholerae. Sera were collected from all animals on days 2, 6, 10, 17, 24, 32, 45 and 60 after infection. Serum protein, immunoglobulins (IgA, IgG, IgM), GOT, and alkaline phosphatases were determined. The results showed that baboons and rhesus monkeys were not susceptible to cholera infection under these experimental conditions. However, we were able to induce a lethal cholera infection in cotton-topped marmosets. In baboons and rhesus monkeys serum IgG levels decreased significantly following inoculation with V. cholerae; however, the ratio of GOT, alkaline phosphatase and antibodies against toxin were only slightly modified.
通过口服、肠内或静脉途径给狒狒、恒河猴和绒顶柽柳猴接种不同菌株的霍乱弧菌，研究它们对霍乱弧菌的免疫反应。在感染后的第2、6、10、17、24、32、45和60天从所有动物采集血清。测定血清蛋白、免疫球蛋白（IgA、IgG、IgM）、谷草转氨酶（GOT）和碱性磷酸酶。结果表明，在这些实验条件下，狒狒和恒河猴对霍乱感染不易感。然而，我们能够在绒顶柽柳猴中诱导出致死性霍乱感染。在狒狒和恒河猴中，接种霍乱弧菌后血清IgG水平显著下降；然而，GOT、碱性磷酸酶和抗毒素抗体的比值仅略有改变。
