Hall R C, Hall R C
Department of Psychiatry, University of Florida, Gainesville, USA.
Psychosomatics. 1999 Nov-Dec;40(6):513-7. doi: 10.1016/S0033-3182(99)71191-6.
A thin, healthy, partial-vegetarian, white female, who was exposed to three doses of lindane (through the application of Kwell), developed a severe case of long-term lindane poisoning. Review of the literature suggests that her toxicity was so severe because of the repetitive nature of her exposure and the fact that she was partly protein restricted when first exposed. She developed profound central nervous system toxicity, as well as skin and gastrointestinal changes, that persisted for 20 months. She was treated with high doses of Valium. It was noted that every time her Valium was diminished below a critical level, her symptoms tended to recur until she had adequately cleared the lindane from her system. We believe this is the longest term of poisoning reported following exposure to an organochloride insecticide. Her symptoms are well explained by the physiology of these compounds as described in the literature. The case is important, for it represents the longest persistence of symptoms clearly associated with poisoning by the potent gamma isomer of BHC-lindane.
一名身材苗条、健康的白人素食女性，因使用了三次林丹（通过涂抹凯素灵）而患上了严重的长期林丹中毒。文献回顾表明，她的中毒情况如此严重，是由于她接触林丹具有重复性，且首次接触时蛋白质摄入部分受限。她出现了严重的中枢神经系统毒性以及皮肤和胃肠道变化，这些症状持续了20个月。她接受了大剂量的安定治疗。值得注意的是，每次她的安定剂量减少到临界水平以下时，症状往往会复发，直到她体内的林丹充分清除。我们认为这是接触有机氯杀虫剂后报告的最长中毒期。文献中描述的这些化合物的生理学原理很好地解释了她的症状。该病例很重要，因为它代表了与BHC - 林丹的强效γ异构体中毒明显相关的症状持续时间最长的情况。
