Sola M C, Rimsza L M, Christensen R D
Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA.
Br J Haematol. 1999 Nov;107(2):458-60. doi: 10.1046/j.1365-2141.1999.01712.x.
Thrombocytopenia and neutropenia are common among neonates in intensive care units. Bone marrow aspirations are sometimes performed as part of their evaluation. However, marrow biopsies have not been reported from living neonates. Since architecture and cellularity cannot generally be accurately assessed from marrow aspirates, we devised a biopsy technique which we successfully applied to five cytopenic neonates (three with severe persistent thrombocytopenia and two with idiopathic neutropenia). This technique used a 19 gauge, half-inch Osgood needle to obtain bone marrow clots from the tibias of small preterm neonates which enabled the assessment of marrow cellularity and architecture. On the basis of our initial experience we have ceased using the traditional bone marrow aspiration technique in neonates and now use this technique exclusively.
血小板减少症和中性粒细胞减少症在重症监护病房的新生儿中很常见。骨髓穿刺有时作为对他们评估的一部分进行。然而，尚未有关于存活新生儿骨髓活检的报道。由于通常无法从骨髓穿刺物中准确评估骨髓结构和细胞成分，我们设计了一种活检技术，并成功应用于五名血细胞减少的新生儿（三名患有严重持续性血小板减少症，两名患有特发性中性粒细胞减少症）。该技术使用19号、半英寸的奥斯古德针从小早产儿的胫骨获取骨髓凝块，从而能够评估骨髓细胞成分和结构。基于我们的初步经验，我们已停止在新生儿中使用传统的骨髓穿刺技术，现在仅使用这种技术。
