在中性等位基因逐步产生情况下有限群体中等位基因频率的分布。
Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles.
作者信息
Kimura M, Ohta T
出版信息
Proc Natl Acad Sci U S A. 1975 Jul;72(7):2761-4. doi: 10.1073/pnas.72.7.2761.
Abstract
A formula for the distribution of allelic frequencies in a finite population is derived assuming stepwise production of multiple alleles. Monte Carlo experiments were performed to check the validity of the formula, and excellent agreement was obtained between theoretical distribution and experimental results. The formula should be useful for analyzing genetic variability in natural populations that can be detected by electrophoretic methods.
摘要
在假设多个等位基因逐步产生的情况下，推导了有限群体中等位基因频率分布的公式。进行了蒙特卡罗实验以检验该公式的有效性，理论分布与实验结果之间获得了极好的一致性。该公式对于分析通过电泳方法可检测的自然群体中的遗传变异性应该是有用的。
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