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具有逐步突变模型的模拟结果及其解释。

Simulation results with stepwise mutation model and their interpretations.

作者信息

Chakraborty R

出版信息

J Mol Evol. 1977 Aug 5;9(4):313-22. doi: 10.1007/BF01796093.

Abstract

Monte Carlo simulations are performed to compare the predictions based on the two presently used theoretical models for studying genetic variations in natural populations, the infinite allele model and the stepwise mutation model. Distribution of heterozygosity is noticed to be similar under these models until the product of population size and mutation rate is large. It is seen that electromorphs with high population frequency usually contain older allels (at the codon level) than an electromorph of low population frequency. The interpretations of these results in explaining the allelic variations at electrophoretic level is also discussed.

摘要

进行蒙特卡罗模拟,以比较基于目前用于研究自然种群遗传变异的两种理论模型——无限等位基因模型和逐步突变模型——的预测结果。在这些模型下,杂合性的分布在种群大小与突变率的乘积较大之前被认为是相似的。可以看出,群体频率高的电形态(在密码子水平上)通常比群体频率低的电形态包含更古老的等位基因。还讨论了这些结果在解释电泳水平上等位基因变异方面的意义。

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