Nakae H, Inaba H, Endo S
Department of Emergency and Critical Care Medicine, Akita University School of Medicine, Japan.
Tohoku J Exp Med. 1999 Jul;188(3):271-3. doi: 10.1620/tjem.188.271.
Procalcitonin (PCT), a precursor of calcitonin, and endotoxin were determined in the burn wound sepsis model in which 21 Sprague-Dawley rats were scalded approximately 30% on their back. On day 2 post burn, the wounds were inoculated 1 x 10(8) colony-forming units of Pseudomonas aeruginosa. On day 5 post burn P. aeruginosa was detected by blood culture in 10 of the 21 rats (47.6%). The mortality rate 7 days after burn was 90.5%. Significant correlations were observed between serum endotoxin levels and serum PCT levels on day 5 post burn (r = 0.860, p<0.001). It was suggested that endotoxin may induce the release of PCT and that measuring the levels of PCT may be useful in diagnosing burn wound sepsis.
在烧伤创面脓毒症模型中测定了降钙素原（PCT，降钙素的前体）和内毒素，该模型中21只Sprague-Dawley大鼠背部约30%体表面积被烫伤。烧伤后第2天，创面接种1×10⁸ 菌落形成单位的铜绿假单胞菌。烧伤后第5天，21只大鼠中有10只（47.6%）血培养检测到铜绿假单胞菌。烧伤后7天的死亡率为90.5%。烧伤后第5天血清内毒素水平与血清PCT水平之间存在显著相关性（r = 0.860，p<0.001）。提示内毒素可能诱导PCT释放，测定PCT水平可能有助于诊断烧伤创面脓毒症。
