动物模型的外部创伤感染。
Animal models of external traumatic wound infections.
机构信息
Wellman Center for Photomedicine, Massachusetts General Hospital, USA.
出版信息
Virulence. 2011 Jul-Aug;2(4):296-315. doi: 10.4161/viru.2.4.16840. Epub 2011 Jul 1.
Abstract
BACKGROUND
Despite advances in traumatic wound care and management, infections remain a leading cause of mortality,morbidity and economic disruption in millions of wound patients around the world. Animal models have become standard tools for studying a wide array of external traumatic wound infections and testing new antimicrobial strategies.
RESULTS
Animal models of external traumatic wound infections reported by different investigators vary in animal species used, microorganism strains, the number of microorganisms applied, the size of the wounds and for burn infections, the length of time the heated object or liquid is in contact with the skin.
METHODS
This review covers experimental infections in animal models of surgical wounds, skin abrasions, burns, lacerations,excisional wounds and open fractures.
CONCLUSIONS
As antibiotic resistance continues to increase,more new antimicrobial approaches are urgently needed.These should be tested using standard protocols for infections in external traumatic wounds in animal models.
摘要
背景
尽管创伤性伤口护理和管理取得了进步，但感染仍然是导致全球数百万伤口患者死亡、发病和经济中断的主要原因。动物模型已成为研究各种外部创伤性伤口感染和测试新抗菌策略的标准工具。
结果
不同研究人员报告的外部创伤性伤口感染的动物模型在使用的动物物种、微生物菌株、应用的微生物数量、伤口大小以及烧伤感染方面，加热物体或液体与皮肤接触的时间长度等方面存在差异。
方法
本文综述了外科伤口、皮肤擦伤、烧伤、撕裂伤、切除术和开放性骨折动物模型中的实验性感染。
结论
随着抗生素耐药性的不断增加，迫切需要更多新的抗菌方法。这些方法应使用动物模型中外部创伤性伤口感染的标准方案进行测试。
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2
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3
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5
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6
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