Slater L J
Department of Oral & Maxillofacial Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
Semin Diagn Pathol. 1999 Nov;16(4):325-32.
Odontogenic sarcoma is a gnathic malignant connective tissue tumor containing epithelium similar to that seen in an ameloblastoma or ameloblastic fibroma. It is a mixed odontogenic tumor in which the epithelial component is benign and the proliferative mesenchymal component is malignant. With each recurrence, the ameloblastic fibrosarcoma demonstrates increasing evidence of stromal cellularity and mitotic activity but diminishing evidence of odontogenic epithelium. If an ameloblastic fibrosarcoma exhibits dysplastic dentin, it can be called an ameloblastic fibrodentinosarcoma, and if it additionally shows focal deposits of dysplastic enamel proteins, it can be designated an ameloblastic fibro-odontosarcoma. A jaw tumor displaying both a carcinomatous and a malignant spindle cell component can be termed an odontogenic carcinosarcoma if it reveals an ameloblastic fibroma-like pattern. If it lacks this pattern, the appellations "spindle-cell ameloblastic carcinoma" or "biphasic ameloblastic sarcomatoid carcinoma" might be preferable. This is a US government work. There are no restrictions on its use.
牙源性肉瘤是一种颌骨恶性结缔组织肿瘤，其中含有类似于成釉细胞瘤或成釉细胞纤维瘤中所见的上皮。它是一种混合性牙源性肿瘤，其中上皮成分是良性的，而增殖性间充质成分是恶性的。随着每次复发，成釉细胞纤维肉瘤显示出基质细胞增多和有丝分裂活性增加的证据，但牙源性上皮的证据减少。如果成釉细胞纤维肉瘤表现出发育异常的牙本质，则可称为成釉细胞纤维牙本质肉瘤，如果它还显示发育异常的釉质蛋白的局灶性沉积，则可称为成釉细胞纤维牙肉瘤。如果颌骨肿瘤同时显示癌性和恶性梭形细胞成分，且呈现成釉细胞纤维瘤样模式，则可称为牙源性癌肉瘤。如果缺乏这种模式，“梭形细胞成釉细胞癌”或“双相成釉细胞肉瘤样癌”这一名称可能更合适。这是美国政府的作品。其使用不受限制。
