Kamath Venkatesh V, Satelur Krishnanand, Yerlagudda Komali
Department of Oral and Maxillofacial Pathology, Dr. Syamala Reddy Dental College, Hospital and Research Center, Munnekolala, Marathalli, Bangalore, India.
Dent Res J (Isfahan). 2012 May;9(3):328-33.
Malignant transformation of ameloblastomas arising from an odontogenic cyst or de novo is well-recognized. Malignancies in ameloblastomas may involve metastasis or a local dysplastic change in the tissue. The latter are classified as ameloblastic carcinomas. A 75-year-old male presented with a mandibular cystic swelling, with no evidence of metastasis. Dysplastic ameloblastic cells with spindle-cell transformation were seen arising from a cystic lining with features of a unicystic ameloblastoma. Immunohistochemically the lesion stained positive with cytokeratin 8,19 and alpha smooth muscle actin, but was negative for vimentin. A diagnosis of spindle-cell ameloblastic carcinoma was made. Spindle-cell ameloblastic carcinomas are rare and this is the second case arising from a unicystic ameloblastoma reported in literature. The recognition of this transformation and inclusion of this entity in the classification of ameloblastic carcinomas is stressed.
由牙源性囊肿发生或新发的成釉细胞瘤的恶性转化已得到充分认识。成釉细胞瘤中的恶性肿瘤可能涉及转移或组织中的局部发育异常变化。后者被归类为成釉细胞癌。一名75岁男性出现下颌囊性肿胀，无转移证据。从具有单囊型成釉细胞瘤特征的囊性衬里中可见具有梭形细胞转化的发育异常的成釉细胞。免疫组织化学显示，该病变细胞角蛋白8、19和α平滑肌肌动蛋白染色呈阳性，但波形蛋白染色呈阴性。诊断为梭形细胞成釉细胞癌。梭形细胞成釉细胞癌罕见，这是文献报道的第二例由单囊型成釉细胞瘤发生的病例。强调了对这种转化的认识以及将该实体纳入成釉细胞癌分类的重要性。
