Wu L T, Anthony J C
Department of Mental Hygiene, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Md. 21205, USA.
Am J Public Health. 1999 Dec;89(12):1837-40. doi: 10.2105/ajph.89.12.1837.
This study builds on previous observations about a suspected causal association linking tobacco smoking with depression. With prospective data, the study sheds new light on the temporal sequencing of tobacco smoking and depressed mood in late childhood and early adolescence.
The epidemiologic sample that was studied consisted of 1731 youths (aged 8-9 to 13-14 years) attending public schools in a mid-Atlantic metropolitan area, who were assessed at least twice from 1989 to 1994. A survival analysis was used to examine the temporal relationship from antecedent tobacco smoking to subsequent onset of depressed mood, as well as from antecedent depressed mood to subsequent initiation of tobacco use.
Tobacco smoking signaled a modestly increased risk for the subsequent onset of depressed mood, but antecedent depressed mood was not associated with a later risk of starting to smoke tobacco cigarettes.
This evidence is consistent with a possible causal link from tobacco smoking to later depressed mood in late childhood and early adolescence, but not vice versa.
本研究基于先前关于吸烟与抑郁症之间疑似因果关系的观察。通过前瞻性数据,该研究为儿童晚期和青少年早期吸烟与情绪低落的时间顺序提供了新的线索。
所研究的流行病学样本包括1731名在大西洋中部大都市地区公立学校就读的青少年(年龄在8 - 9岁至13 - 14岁之间),他们在1989年至1994年期间至少接受了两次评估。采用生存分析来检验从先前吸烟到随后情绪低落发作的时间关系,以及从先前情绪低落发作到随后开始吸烟的时间关系。
吸烟表明随后情绪低落发作的风险略有增加,但先前情绪低落与后来开始吸烟的风险无关。
这一证据与儿童晚期和青少年早期吸烟与后来情绪低落之间可能存在因果关系一致,但反之则不然。