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体外雌二醇处理对雄性和雌性青蛙肝脏培养物中卵黄蛋白原合成的调节作用。

Synthesis of vitellogenin in cultures of male and female frog liver regulated by estradiol treatment in vitro.

作者信息

Wangh L J, Knowland J

出版信息

Proc Natl Acad Sci U S A. 1975 Aug;72(8):3172-5. doi: 10.1073/pnas.72.8.3172.

DOI:10.1073/pnas.72.8.3172
PMID:1059103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432943/
Abstract

Using the frog Xenopus laevis, we show that the addition of physiological concentrations of estradiol to cultures of liver from untreated males rapidly induces the synthesis of large amounts of vitellogenin. Sustained synthesis of vitellogenin requires continuous exposure to estradiol. A nonestrogenic steroid, dexamethasone, does not induce vitellogenin synthesis but does induce increased synthesis of a different protein in liver cultures.

摘要

利用非洲爪蟾，我们发现，向未处理雄性个体的肝脏培养物中添加生理浓度的雌二醇，会迅速诱导大量卵黄蛋白原的合成。卵黄蛋白原的持续合成需要持续暴露于雌二醇。一种非雌激素类固醇地塞米松不会诱导卵黄蛋白原的合成，但会诱导肝脏培养物中另一种蛋白质的合成增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63c/432943/25ce6c2cbf8a/pnas00051-0344-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63c/432943/ac32b205f058/pnas00051-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63c/432943/58b8497b7370/pnas00051-0344-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63c/432943/25ce6c2cbf8a/pnas00051-0344-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63c/432943/ac32b205f058/pnas00051-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63c/432943/58b8497b7370/pnas00051-0344-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e63c/432943/25ce6c2cbf8a/pnas00051-0344-b.jpg

相似文献

1
Synthesis of vitellogenin in cultures of male and female frog liver regulated by estradiol treatment in vitro.体外雌二醇处理对雄性和雌性青蛙肝脏培养物中卵黄蛋白原合成的调节作用。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3172-5. doi: 10.1073/pnas.72.8.3172.
2
Investigation of the mechanisms and consequences of steroid hormone action on vitellogenin synthesis in Xenopus laevis.非洲爪蟾中类固醇激素对卵黄蛋白原合成作用的机制及后果研究。
Symp Soc Dev Biol. 1976(34):151-69.
3
Induction of vitellogenin synthesis in Xenopus laevis tadpoles.非洲爪蟾蝌蚪中卵黄蛋白原合成的诱导
Differentiation. 1978 Nov 15;12(1):47-51. doi: 10.1111/j.1432-0436.1979.tb00989.x.
4
Direct induction by estradiol on vitellogenin synthesis in organ cultures of male Xenopus laevis liver.雌二醇对雄性非洲爪蟾肝脏器官培养物中卵黄蛋白原合成的直接诱导作用。
Cell. 1976 Jan;7(1):131-9. doi: 10.1016/0092-8674(76)90263-4.
5
Parenchymal cells purified from Xenopus liver and maintained in primary culture synthesize vitellogenin in response to estradiol-17 beta and serum albumin in response to dexamethasone.从非洲爪蟾肝脏中纯化并维持在原代培养中的实质细胞，会响应17β-雌二醇合成卵黄蛋白原，并响应地塞米松合成血清白蛋白。
Dev Biol. 1979 Jun;70(2):479-99. doi: 10.1016/0012-1606(79)90040-x.
6
Thyroid hormones are corequisites for estradiol-17beta in vitro induction of Xenopus vitellogenin synthesis and secretion.
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7
Estradiol-induced accumulation of vitellogenin mRNA and secretion of vitellogenin in liver cultures of Xenopus.雌二醇诱导非洲爪蟾肝脏培养物中卵黄蛋白原mRNA的积累及卵黄蛋白原的分泌。
Mol Cell Endocrinol. 1978 Nov;12(2):151-66. doi: 10.1016/0303-7207(78)90111-9.
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In vitro translation and estradiol-17beta induction of Xenopus laevis vitellogenin messenger RNA.非洲爪蟾卵黄蛋白原信使核糖核酸的体外翻译及17β-雌二醇诱导
J Biol Chem. 1976 May 25;251(10):3105-111.
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Influence of CI-628 (CN-55, 945-27) on estrogen-induced vitellogenin synthesis and on the ultrastructure of hepatocytes in male Xenopus laevis.CI-628（CN-55,945-27）对雌激素诱导的非洲爪蟾雄性肝细胞卵黄蛋白原合成及超微结构的影响。
Eur J Cell Biol. 1979 Dec;20(2):143-9.
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Regulation by estrogen of the vitellogenin gene.雌激素对卵黄蛋白原基因的调控。
Proc Natl Acad Sci U S A. 1977 Jun;74(6):2384-8. doi: 10.1073/pnas.74.6.2384.

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本文引用的文献

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[Demonstration of estrogenic steroid in the immature ovary of Xenopus laevis Daudin, and the estrogen cycle during laying].[非洲爪蟾未成熟卵巢中雌激素甾体的显示及产卵期间的雌激素循环]
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Post-translational phosphorylation of phosvitin.卵黄高磷蛋白的翻译后磷酸化
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Resolution and isolation of avian and amphibian yolk-granule proteins using TEAE-cellulose.使用三乙氨基乙基纤维素对鸟类和两栖类动物卵黄颗粒蛋白进行分离和纯化
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Vitellogenin induction by xenobiotic estrogens in the red-eared turtle and African clawed frog.外来雌激素对红耳龟和非洲爪蟾卵黄蛋白原的诱导作用
Environ Health Perspect. 1995 May;103 Suppl 4(Suppl 4):19-25. doi: 10.1289/ehp.95103s419.
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Protein synthesis with membrane-bound polysomes and albumin messenger RNA from livers of mutant mice.利用来自突变小鼠肝脏的膜结合多核糖体和白蛋白信使核糖核酸进行蛋白质合成。
Mol Cell Biochem. 1981 Apr 13;36(1):29-35. doi: 10.1007/BF02354829.
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Activation of vitellogenin gene transcription is a direct response to estrogen in Xenopus laevis liver.在非洲爪蟾肝脏中，卵黄蛋白原基因转录的激活是对雌激素的直接反应。
Nucleic Acids Res. 1982 Dec 20;10(24):8273-84. doi: 10.1093/nar/10.24.8273.
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Primary induction of vitellogenin synthesis in monolayer cultures of amphibian hepatocytes.两栖类肝细胞单层培养中卵黄蛋白原合成的初级诱导
J Cell Biol. 1980 Feb;84(2):468-75. doi: 10.1083/jcb.84.2.468.
8
Partial purification of estradiol receptor from Xenopus laevis liver and levels of receptor in relation to estradiol concentration.从非洲爪蟾肝脏中对雌二醇受体进行部分纯化以及受体水平与雌二醇浓度的关系。
EMBO J. 1983;2(6):973-7. doi: 10.1002/j.1460-2075.1983.tb01530.x.
9
Mechanism of estrogen action: indirect effect of estradiol-17 beta on proliferation of quail oviduct cells.雌激素作用机制：17β-雌二醇对鹌鹑输卵管细胞增殖的间接作用。
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1621-5. doi: 10.1073/pnas.80.6.1621.
10
Comparative analysis of Xenopus tropicalis and Xenopus laevis vitellogenin gene sequences.热带爪蟾和非洲爪蟾卵黄蛋白原基因序列的比较分析。
Nucleic Acids Res. 1982 Mar 11;10(5):1515-33. doi: 10.1093/nar/10.5.1515.
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4
Studies on amphibian yolk. 8. The estrogen-induced hepatic synthesis of a serum lipophosphoprotein and its selective uptake by the ovary and trasformation into yolk platelet proteins in Xenopus laevis.两栖动物卵黄研究。8. 雌激素诱导非洲爪蟾血清脂磷蛋白的肝脏合成及其被卵巢选择性摄取并转化为卵黄小板蛋白
Dev Biol. 1969 May;19(5):498-526. doi: 10.1016/0012-1606(69)90085-2.
5
Comparative effects of the oestrogens and other steroid hormones on serum lipids and proteins in Xenopus laevis Daudin.雌激素和其他类固醇激素对非洲爪蟾血清脂质和蛋白质的比较作用
J Endocrinol. 1969 Jan;43(1):47-53. doi: 10.1677/joe.0.0430047.
6
The effects of oestrogen and gonadotrophins on lipid and protein metabolism in Xenopus laevis Daudin.雌激素和促性腺激素对非洲爪蟾（Xenopus laevis Daudin）脂质和蛋白质代谢的影响。
J Endocrinol. 1968 Apr;40(4):439-56. doi: 10.1677/joe.0.0400439.
7
Studies on amphibian yolk. IX. Xenopus vitellogenin.两栖动物卵黄研究。IX. 非洲爪蟾卵黄生成素。
Biochim Biophys Acta. 1970 Jul 21;215(1):176-83. doi: 10.1016/0304-4165(70)90400-9.
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Chemical composition of an oestrogen-induced calcium-binding glycolipophosphoprotein in Xenopus laevis.非洲爪蟾中一种雌激素诱导的钙结合糖脂磷蛋白的化学成分
Biochem J. 1971 Mar;122(1):107-13. doi: 10.1042/bj1220107.
9
A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.一种用于检测聚丙烯酰胺凝胶中氚标记蛋白质和核酸的胶片检测方法。
Eur J Biochem. 1974 Jul 1;46(1):83-8. doi: 10.1111/j.1432-1033.1974.tb03599.x.
10
Precursor-product relationship between amphibian vitellogenin and the yolk proteins, lipovitellin and phosvitin.两栖动物卵黄蛋白原与卵黄蛋白、脂卵黄蛋白和卵黄高磷蛋白之间的前体-产物关系。
J Biol Chem. 1974 May 10;249(9):2897-903.