Maury P
Eur J Clin Invest. 1978 Dec;8(6):405-9. doi: 10.1111/j.1365-2362.1978.tb00872.x.
The urinary excretion of sialic acid-containing trisaccharides in patients with active rheumatoid arthritis was studied. Sialyl-lactose and sialyl-N-acetyllactosamine were identified and their excretion patterns studied by thin layer and gas chromatography. The urinary output of sialyl-lactose was greater in patients with active rheumatoid arthritis (48.2 +/- 6.1 mg/24 h, SEM, n = 6) than in healthy subjects (19.8 +/- 3.7 mg/24 h, SEM, n = 5; P less than 0.01). The excretion of sialyl-N-acetyllactosamine was also higher in the rheumatoid group (18.5 +/- 2.1 mg/24 h, SEM, n = 6) than in the controls (11.1 +/- 1.2 mg/24 h, SEM, n = 5; P less than 0.05). The qualitative excretion patterns of the sialyl-oligosaccharide fraction were similar for the two groups as judged from the thin layer chromatograms. Correlating the results with the clinical state of the patients with rheumatoid arthritis suggests that the urinary level of the sialyl-oligosaccharides reflects the activity of the disease. A proposed mechanism for the increased excretion of sialic acid-containing trisaccharides in rheumatoid arthritis is presented.
对活动期类风湿关节炎患者含唾液酸三糖的尿排泄情况进行了研究。鉴定出唾液酸乳糖和唾液酸-N-乙酰乳糖胺，并通过薄层色谱法和气相色谱法研究了它们的排泄模式。活动期类风湿关节炎患者的唾液酸乳糖尿量（48.2±6.1毫克/24小时，标准误，n = 6）高于健康受试者（19.8±3.7毫克/24小时，标准误，n = 5；P<0.01）。类风湿关节炎组的唾液酸-N-乙酰乳糖胺排泄量（18.5±2.1毫克/24小时，标准误，n = 6）也高于对照组（11.1±1.2毫克/24小时，标准误，n = 5；P<0.05）。从薄层色谱图判断，两组唾液酸寡糖组分的定性排泄模式相似。将结果与类风湿关节炎患者的临床状态相关联表明，唾液酸寡糖的尿水平反映了疾病的活动度。本文提出了类风湿关节炎中含唾液酸三糖排泄增加的一种推测机制。
