一种基因重组起始的机制。
A mechanism for initiation of genetic recombination.
作者信息
Wagner R E, Radman M
出版信息
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3619-22. doi: 10.1073/pnas.72.9.3619.
Abstract
A mechanism for the initiation of genetic recombination is proposed. Its key features are the pairing, nicking, and cross-annealing of palindromic loops, i.e., structures formed by DNA with sequences of inverted complementary repeats. This mechanism may provide a simple, yet specific means of producing crossed strand connections between homologous DNA duplexes to form structures which can be intermediates in the process of genetic recombination.
摘要
提出了一种基因重组起始机制。其关键特征是回文环的配对、切口和交叉退火，即由具有反向互补重复序列的DNA形成的结构。该机制可能提供一种简单而特异的方式，在同源DNA双链体之间产生交叉链连接，以形成可作为基因重组过程中间体的结构。
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