Kel-Margoulis O V, Romashchenko A G, Kolchanov N A, Wingender E, Kel A E
Institute of Cytology, SB RAN, 10 Lavrentyev pr., 630090, Novosibirsk, Russia.
Nucleic Acids Res. 2000 Jan 1;28(1):311-5. doi: 10.1093/nar/28.1.311.
COMPEL is a database on composite regulatory elements, the basic structures of combinatorial regulation. Composite regulatory elements contain two closely situated binding sites for distinct transcription factors and represent minimal functional units providing combinatorial transcriptional regulation. Both specific factor-DNA and factor-factor interactions contribute to the function of composite elements (CEs). Information about the structure of known CEs and specific gene regulation achieved through such CEs appears to be extremely useful for promoter prediction, for gene function prediction and for applied gene engineering as well. The structure of the relational model of COMPEL is determined by the concept of molecular structure and regulatory role of CEs. Based on the set of a particular CE, a program has been developed for searching potential CEs in gene regulatory regions. WWW search and browse routines were developed for COMPEL release 3.0. The COMPEL database equipped with the search and browse tools is available at http://compel.bionet.nsc.ru/. The program for prediction of potential CEs of NFAT type is available at http://compel.bionet.nsc. ru/FunSite.html and http://transfac.gbf.de/dbsearch/funsitep/ s_comp.html
COMPEL是一个关于复合调控元件的数据库,复合调控元件是组合调控的基本结构。复合调控元件包含两个紧密相邻的不同转录因子结合位点,代表提供组合转录调控的最小功能单元。特定的因子 - DNA相互作用和因子 - 因子相互作用都对复合元件(CEs)的功能有贡献。关于已知CEs的结构以及通过这些CEs实现的特定基因调控的信息,对于启动子预测、基因功能预测以及应用基因工程似乎都极其有用。COMPEL关系模型的结构由CEs的分子结构和调控作用概念决定。基于一组特定的CE,已经开发了一个程序用于在基因调控区域搜索潜在的CEs。为COMPEL 3.0版本开发了万维网搜索和浏览程序。配备搜索和浏览工具的COMPEL数据库可在http://compel.bionet.nsc.ru/获取。预测NFAT类型潜在CEs的程序可在http://compel.bionet.nsc.ru/FunSite.html和http://transfac.gbf.de/dbsearch/funsitep/s_comp.html获取