Sonnleitner B
University of Applied Sciences, Winterthur, Switzerland.
Adv Biochem Eng Biotechnol. 2000;66:1-64. doi: 10.1007/3-540-48773-5_1.
Modern bioprocesses are monitored by on-line sensing devices mounted either in situ or externally. In addition to sensor probes, more and more analytical subsystems are being exploited to monitor the state of a bioprocess on-line and in real time. Some of these subsystems deliver signals that are useful for documentation only, other, less delayed systems generate signals useful for closed loop process control. Various conventional and non-conventional monitoring instruments are evaluated; their usefulness, benefits and associated pitfalls are discussed.
现代生物工艺通过原位安装或外部安装的在线传感设备进行监测。除了传感器探头外,越来越多的分析子系统被用于在线实时监测生物工艺的状态。其中一些子系统仅提供用于记录的信号,而其他延迟较小的系统则产生对闭环过程控制有用的信号。对各种传统和非传统监测仪器进行了评估;讨论了它们的实用性、优点和相关的缺陷。