a Division of Biotechnology , IFM, Linköping University , Linköping , Sweden.
Crit Rev Biotechnol. 2018 Feb;38(1):106-121. doi: 10.1080/07388551.2017.1312271. Epub 2017 Apr 20.
This review provides an overview and a critical discussion of novel possibilities of applying soft sensors for on-line monitoring and control of industrial bioprocesses. Focus is on bio-product formation in the upstream process but also the integration with other parts of the process is addressed. The term soft sensor is used for the combination of analytical hardware data (from sensors, analytical devices, instruments and actuators) with mathematical models that create new real-time information about the process. In particular, the review assesses these possibilities from an industrial perspective, including sensor performance, information value and production economy. The capabilities of existing analytical on-line techniques are scrutinized in view of their usefulness in soft sensor setups and in relation to typical needs in bioprocessing in general. The review concludes with specific recommendations for further development of soft sensors for the monitoring and control of upstream bioprocessing.
本综述概述并批判性地讨论了将软传感器应用于工业生物过程在线监测和控制的新可能性。重点关注上游过程中的生物产物形成，但也涉及与过程其他部分的集成。软传感器一词是指分析硬件数据（来自传感器、分析设备、仪器和执行器）与数学模型的组合，这些模型创建有关过程的新实时信息。特别是，该综述从工业角度评估了这些可能性，包括传感器性能、信息价值和生产经济性。鉴于其在软传感器设置中的有用性以及与一般生物加工的典型需求的关系，审查了现有在线分析技术的能力。综述最后为上游生物加工监测和控制软传感器的进一步发展提出了具体建议。
