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(N-巴比妥基)苯基和环己基链烷酸及其某些衍生物作为潜在的抗炎剂。

(N-Barbituryl)phenyl- and cyclohexylalkanoic acids and some of their derivatives as potential anti-inflammatory agents.

作者信息

Stankiewicz K, Bobrański B

出版信息

Farmaco Sci. 1978 Oct;33(10):729-39.

PMID:105934
Abstract

A series of p-(N-barbituryl)phenyl- and cyclohexylalkanoic acids and their esters were synthesized. The preliminary pharmacological screening using the carrageenin, xylene and cotton tests revealed strong anti-inflammatory activity of several compounds in some of the tests performed, compound (Ij) being active in all the tests.

摘要

合成了一系列对-(N-巴比妥基)苯基和环己基链烷酸及其酯。使用角叉菜胶、二甲苯和棉球试验进行的初步药理筛选显示,在进行的一些试验中,几种化合物具有很强的抗炎活性,化合物(Ij)在所有试验中均有活性。

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