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Studies on the Ritter reaction. I. Synthesis of 3-/5-barbituryl/-propanesulfonic acids with anti-inflammatory activity.

作者信息

Radzicka A, Konieczny M

出版信息

Arch Immunol Ther Exp (Warsz). 1982;30(5-6):421-32.

PMID:7184491
Abstract

Under the condition of the Ritter reaction the allyl group bound to C5 of the barbituric ring was observed to transform, due to addition of sulfuric acid, into beta-sulfooxy-propane-sulfonic or beta-hydroxy-propanesulfonic group. Inner anhydrides of the structure of beta-sulfone or carbyl sulfate are the intermediate products of these reactions. Well water-soluble calcium salts of the synthetized acids were pharmacologically analyzed.

摘要

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