Sladowska H
Farmaco Sci. 1976 Oct;31(10):714-30.
The synthesis and investigation of the structure of N-carboxyalkyl derivatives of barbituric acids are described. In the solid state 3-carboxymethyl-1-phenylbarbitone has the structure of a hemiketal, the corresponding 1-cyclohexyl derivative was not cyclized to the hemiketal and 3-carboxymethyl-5-ethyl-1-phenylbarbituric acid was a mixture of the cyclized and open structures. Some of the compounds were found to be very weak inhibitors of prostaglandin synthetase.
本文描述了巴比妥酸N-羧基烷基衍生物的合成及其结构研究。在固态下，3-羧甲基-1-苯基巴比妥酸具有半缩酮结构，相应的1-环己基衍生物未环化生成半缩酮，而3-羧甲基-5-乙基-1-苯基巴比妥酸是环化结构和开链结构的混合物。发现某些化合物是前列腺素合成酶的非常弱的抑制剂。
