Argani P, Askin F B, Colombani P, Perlman E J
Department of Pathology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Pediatr Dev Pathol. 2000 Jan-Feb;3(1):87-90. doi: 10.1007/s100240050011.
We report a unique case of a minute, occult synovial sarcoma of the lung detected intraoperatively during a pneumothorax repair in a 17-year-old boy. No alternative primary site could be detected upon complete body imaging studies and physical examinations. The diagnosis was confirmed by demonstration of the characteristic SYT/SSX gene fusion by reverse transcriptase polymerase chain reaction (RT-PCR) performed upon RNA extracted from the paraffin block of the biopsy. This case demonstrates the utility of this technique in diagnostic pathology.
我们报告了一例独特的病例，一名17岁男孩在气胸修复手术中意外发现了微小的隐匿性肺滑膜肉瘤。全身影像学检查和体格检查均未发现其他原发部位。通过对活检石蜡块提取的RNA进行逆转录聚合酶链反应（RT-PCR），证实存在特征性的SYT/SSX基因融合，从而确诊。该病例展示了这项技术在诊断病理学中的应用价值。
