太空飞行期间宇航员唾液中爱泼斯坦-巴尔病毒的发生率。
Incidence of Epstein-Barr virus in astronaut saliva during spaceflight.
作者信息
Payne D A, Mehta S K, Tyring S K, Stowe R P, Pierson D L
机构信息
Department of Pathology, University of Texas Medical Branch, Galveston, USA.
出版信息
Aviat Space Environ Med. 1999 Dec;70(12):1211-3.
BACKGROUND
Astronauts experience psychological and physical stresses that may result in reactivation of latent viruses during space-flight, potentially increasing the risk of disease among crewmembers.
HYPOTHESIS
The shedding of Epstein-Barr virus (EBV) in the saliva of astronauts will increase during spaceflight.
METHODS
A total of 534 saliva specimens were collected from 11 EBV-seropositive astronauts before, during, and after four space shuttle missions. The presence of EBV DNA in saliva, assessed by polymerase chain reaction (PCR), was used to determine shedding patterns before, during, and after space-flight.
RESULTS
EBV DNA was detected more frequently before flight than during (p < 0.001) or after (p < 0.01) flight. No significant difference between the inflight and postflight periods was detected in the frequency of occurrence of EBV DNA.
CONCLUSIONS
The increased frequency of shedding of EBV before flight suggests that stress levels may be greater before launch than during or after spaceflight.
背景
宇航员会经历心理和生理压力，这可能导致潜伏病毒在太空飞行期间重新激活，从而可能增加机组人员患病的风险。
假设
宇航员唾液中爱泼斯坦 - 巴尔病毒（EBV）的排出量在太空飞行期间会增加。
方法
在四次航天飞机任务之前、期间和之后，从11名EBV血清反应阳性的宇航员那里总共收集了534份唾液样本。通过聚合酶链反应（PCR）评估唾液中EBV DNA的存在情况，以确定太空飞行前、期间和之后的排出模式。
结果
飞行前检测到EBV DNA的频率高于飞行期间（p < 0.001）或飞行后（p < 0.01）。在飞行中和飞行后期间，EBV DNA出现的频率未检测到显著差异。
结论
飞行前EBV排出频率增加表明发射前的压力水平可能比太空飞行期间或之后更大。
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