Varshavskiĭ V A, Proskurneva E P, Gasanov A B, Severgina L O, Shestakova L A
I. M. Sechenov Moscow Medical Academy, Moscow.
Arkh Patol. 1999 Sep-Oct;61(5):40-6.
Modern methods allow to detail morphological classification of chronic glomerulonephritis, to adapt it to the clinical classification and to recommend it for practical use. This specification concerns minimal changes and a group of mesangial chronic glomerulonephritis. The term "minimal changes" is a light-microscopic definition and covers rather a heterogeneous group of diseases or their initial manifestations. Differential diagnosis of these diseases is feasible only at the electron microscopic level. A group of chronic glomerulonephritis (mesangioproliferative and mesangiocapillary) includes variants distinguished on the basis of immunohistochemical, light microscopic and electron microscopic methods. Of them, the immunohistochemical method is most valuable for differentiation of mesangioproliferative glomerulonephritis.
现代方法能够详细阐述慢性肾小球肾炎的形态学分类，使其与临床分类相适应，并推荐用于实际应用。本规范涉及微小病变和一组系膜性慢性肾小球肾炎。“微小病变”这一术语是光镜下的定义，涵盖了相当一组异质性疾病或其初始表现。这些疾病的鉴别诊断仅在电子显微镜水平上可行。一组慢性肾小球肾炎（系膜增生性和系膜毛细血管性）包括基于免疫组织化学、光镜和电子显微镜方法区分的变体。其中，免疫组织化学方法在系膜增生性肾小球肾炎的鉴别中最有价值。
