Fluhr J W, Gloor M, Lehmann L, Lazzerini S, Distante F, Berardesca E
Department of Dermatology, Städt. Klinikum Karlsruhe, Germany.
Acta Derm Venereol. 1999 Nov;79(6):418-21. doi: 10.1080/000155599750009825.
Two studies were performed to evaluate the influence of glycerol on the recovery of damaged stratum corneum barrier function. Measurements of transepidermal water loss and capacitance were conducted in a 3-day follow-up after tape stripping (study 1) and a 7-day follow-up after a barrier damage due to a repeated washing with sodium lauryl sulphate. In study 1 a faster barrier repair (transepidermal water loss) was monitored in glycerol-treated sites. Significant differences between glycerol open vs. untreated and glycerol occluded vs. untreated were observed at day 3. Stratum corneum hydration showed significantly higher values in the sites treated with glycerol+occlusion, compared with all other sites. In study 2 a faster barrier repair was seen in glycerol-treated sites, with significant differences against untreated and base-treated sites 7 days after the end of the treatment. Stratum corneum hydration showed highest values in the glycerol treated sites after 3 days of treatment. Glycerol creates a stimulus for barrier repair and improves the stratum corneum hydration; stratum corneum hydration is not strictly related to barrier homeostasis and can be optimized by different mechanisms and pathways. The observed effects were based on the modulation of barrier repair and were not biased by the humectant effect of glycerol. As the glycerol-induced recovery of barrier function and stratum corneum hydration were observed even 7 days after the end of treatment, glycerol can be regarded as a barrier stabilizing and moisturizing compound.
进行了两项研究以评估甘油对受损角质层屏障功能恢复的影响。在胶带剥离后的3天随访（研究1）以及用十二烷基硫酸钠反复清洗导致屏障受损后的7天随访中，进行了经表皮水分流失和电容测量。在研究1中，在甘油处理部位监测到屏障修复更快（经表皮水分流失）。在第3天观察到甘油开放组与未处理组以及甘油封闭组与未处理组之间存在显著差异。与所有其他部位相比，甘油+封闭处理部位的角质层水合作用显示出显著更高的值。在研究2中，在甘油处理部位观察到屏障修复更快，在治疗结束7天后，与未处理组和基础处理组相比存在显著差异。治疗3天后，甘油处理部位的角质层水合作用值最高。甘油为屏障修复创造了刺激并改善了角质层水合作用；角质层水合作用与屏障稳态并不严格相关，可通过不同机制和途径进行优化。观察到的效果基于屏障修复的调节，并非受甘油保湿作用的影响。由于在治疗结束后7天仍观察到甘油诱导的屏障功能和角质层水合作用的恢复，甘油可被视为一种屏障稳定和保湿化合物。
