Shenyang No.7 People's Hospital, Shenyang 110003, Liaoning, China.
Dermatology Hospital, Southern Medical University, Guangdong 510091, China.
Aging (Albany NY). 2020 Mar 27;12(6):5551-5565. doi: 10.18632/aging.102946.
Chronologically-aged skin displays multiple functional changes in both the dermis and the epidermis. It appears that epidermal dysfunction, compromised permeability homeostasis, reduced stratum corneum hydration and elevated skin surface pH predispose to the development of aging-associated cutaneous and extracutaneous disorders. Improvements in epidermal function have been shown to be an effective alternative therapy in the prevention and treatment of some aging-associated cutaneous disorders, including eczematous dermatitis, pruritus, and xerosis. Recent studies demonstrated that epidermal dysfunction leads to the development of chronic, low-grade systemic inflammation, termed 'inflammaging,' which is linked to the development of aging-associated systemic disorders. Thus, correction of epidermal dysfunction could comprise a novel strategy in the prevention and treatment of aging-associated systemic disorders as well. In this review, we summarize aging-associated alterations in epidermal function, their underlying mechanisms, and their clinical significance. Regimens to improve epidermal function in the elderly are also discussed.
随着年龄的增长，皮肤在真皮和表皮中均表现出多种功能变化。似乎表皮功能障碍、通透性稳态受损、角质层水合作用降低和皮肤表面 pH 值升高会导致与衰老相关的皮肤和皮肤外疾病的发生。改善表皮功能已被证明是预防和治疗某些与衰老相关的皮肤疾病的有效替代疗法，包括湿疹性皮炎、瘙痒和干燥症。最近的研究表明，表皮功能障碍会导致慢性低度系统性炎症的发展，称为“炎症衰老”，这与与衰老相关的系统性疾病的发展有关。因此，纠正表皮功能障碍可能是预防和治疗与衰老相关的系统性疾病的一种新策略。在这篇综述中，我们总结了与衰老相关的表皮功能改变及其潜在机制和临床意义。还讨论了改善老年人表皮功能的方案。
