David R B, Hadfield M G, Vines F S, Maurer H M
Pediatrics. 1975 Nov;56(5):793-6.
The case of a 7-year-old child with acute lymphocytic leukemia who, while in relapse, developed a superior sagittal sinus thrombosis is documented by angiography and post-mortem examination. Review of the literature suggests that cerebral spinal fluid (CSF) pleocytosis which usually accompanies the arachnoid infiltration of central nervous system (CNS) leukemia may be absent in some patients as in this case. In the absence of CSF pleocytosis, cerebral venous sinus thrombosis may mimic the other signs and symptoms of CNS leukemia and consequently may be a more frequent complication of acute leukemia than is presently appreciated. Therapy directed to the CSF axis generally would not under these circumstances be appropriate.
一名7岁急性淋巴细胞白血病患儿在复发时发生上矢状窦血栓形成，血管造影和尸检记录了该病例。文献回顾表明，中枢神经系统（CNS）白血病蛛网膜浸润时通常伴随的脑脊液（CSF）细胞增多症在某些患者中可能不存在，如本病例。在没有脑脊液细胞增多症的情况下，脑静脉窦血栓形成可能会模仿中枢神经系统白血病的其他体征和症状，因此可能是急性白血病比目前认识到的更常见的并发症。在这些情况下，针对脑脊液轴的治疗通常不合适。
