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肝脏脂肪酸合成酶合成的调控：脂肪酸合成酶抗体与多核糖体的结合

Regulation of synthesis of hepatic fatty acid synthetase: binding of fatty acid synthetase antibodies to polysomes.

作者信息

Alberts A W, Strauss A W, Hennessy S, Vagelos P R

出版信息

Proc Natl Acad Sci U S A. 1975 Oct;72(10):3956-60. doi: 10.1073/pnas.72.10.3956.

DOI:10.1073/pnas.72.10.3956
PMID:1060077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC433116/
Abstract

Mammalian fatty acid synthetase was shown to be composed of two peptides, molecular weight 240,000, after dissociation with sodium dodecyl sulfate. Rat liver polysomes that synthesize fatty acid synthetase were identified by sucrose gradient analysis of polysomes that had been reacted with 125I-labeled antibody against fatty acid synthetase. The binding of 125I-labeled antibody to polysomes was found to correlate with the rate of hepatic fatty acid synthesis in various nutritional conditions.

摘要

用十二烷基硫酸钠解离后，哺乳动物脂肪酸合成酶显示由两条分子量为240,000的肽组成。通过对与125I标记的脂肪酸合成酶抗体反应后的多核糖体进行蔗糖梯度分析，鉴定出合成脂肪酸合成酶的大鼠肝脏多核糖体。发现在各种营养条件下，125I标记的抗体与多核糖体的结合与肝脏脂肪酸合成速率相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e290/433116/6a6e27c3a423/pnas00053-0175-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e290/433116/6a6e27c3a423/pnas00053-0175-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e290/433116/6a6e27c3a423/pnas00053-0175-a.jpg

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