Spring G K
J Clin Psychiatry. 1979 Mar;40(3):135-8.
Four cases on a combination of lithium and thioridazine developed severe neurotoxic symptoms, e.g., delirium, seizures, encephalopathy and grossly abnormal EEG's. All patients had been on lithium without thioridazine prior to and after the neurotoxic episode with no complications or EEG changes. The possible risk of combining lithium and neuroleptics (thioridazine) is discussed and repeated EEGs are recommended as a preventive measure.
4例联用锂盐和硫利达嗪的患者出现了严重的神经毒性症状，如谵妄、癫痫发作、脑病以及脑电图明显异常。在神经毒性发作前后，所有患者均单独服用锂盐，未服用硫利达嗪，且无并发症或脑电图改变。文中讨论了联用锂盐和抗精神病药物（硫利达嗪）可能存在的风险，并建议重复进行脑电图检查作为预防措施。
