Igarashi M, Tsuchida T, Kinoshita N, Kamijima M, Sawa R, Sawa T, Naganawa H, Hamada M, Takeuchi T, Yamazaki K, Ishizuka M
Institute of Microbial Chemistry, Tokyo, Japan.
J Antibiot (Tokyo). 1998 Feb;51(2):123-9. doi: 10.7164/antibiotics.51.123.
A novel 19-membered macrocyclic lactam antibiotic, cremimycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MJ635-86F5, was identified as a member of Streptomyces. Cremimycin was isolated from the mycelial cake by extraction with CHCl3-MeOH and precipitation with hexane-MeOH. The structure of cremimycin was determined by spectroscopic study. Cremimycin showed broad antimicrobial activities against Gram-positive bacteria including MRSA.
从一株放线菌的培养液中分离出一种新型的19元大环内酰胺抗生素——cremimycin。产生该抗生素的菌株命名为MJ635 - 86F5，经鉴定属于链霉菌属。通过用氯仿 - 甲醇萃取以及用己烷 - 甲醇沉淀，从菌丝饼中分离出cremimycin。通过光谱研究确定了cremimycin的结构。cremimycin对包括耐甲氧西林金黄色葡萄球菌（MRSA）在内的革兰氏阳性菌显示出广泛的抗菌活性。
