Grillner S
Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Curr Opin Neurobiol. 1999 Dec;9(6):663-9. doi: 10.1016/s0959-4388(99)00036-7.
A major challenge for current research in neuroscience is to understand the intrinsic operation of the functional modules of the central nervous system, such as those formed by cortical columns and the neuronal networks controlling motor behaviour. Most vertebrate experimental models used in network analyses involve developing nervous systems, which are in rapid transition with regard to their cellular properties and the expression of different ion channels. Recent advances in our understanding of the cellular and circuit properties of motor networks are making it possible to decipher the mechanisms involved in vertebrate motor pattern generation.
当前神经科学研究面临的一个主要挑战是了解中枢神经系统功能模块的内在运作，例如由皮质柱和控制运动行为的神经元网络形成的功能模块。网络分析中使用的大多数脊椎动物实验模型都涉及发育中的神经系统，这些系统在细胞特性和不同离子通道的表达方面处于快速转变状态。我们对运动网络的细胞和回路特性的理解最近取得的进展，使得解读脊椎动物运动模式产生所涉及的机制成为可能。
